International Journal of Medical Informatics
Volume 77, Issue 6 , Pages 365-376 , June 2008

The impact of computerized physician medication order entry in hospitalized patients—A systematic review

Received 30 January 2007 ,Revised 26 September 2007 ,Accepted 3 October 2007.

References 

  1. Bell DS, Cretin S, Marken RS, et al. A conceptual framework for evaluating outpatient electronic prescribing system based on their functional capacity. J. Am. Med. Inform. Assoc. 2004;11:60–70
  2. Kohn LT, Corrigan JM, Donaldson MS. To Err is Human: Building a Safer Health Syst.. Washington, DC: National Academy Press; 1999;
  3. Bates DW, Cullen DJ, Laird N, et al. Incidence of adverse drug events and potential adverse drug events. JAMA. 1995;274:29–34
  4. Bates DW, Burrows AM, Grossman DG, et al. Top priority actions for preventing adverse drug events in hospitals: recommendation of an expert panel. Am. J. Health-Syst. Ph. 1996;53:747–751
  5. Oliven A, Michalake I, Zalman D, et al. Prevention of prescription errors by computerized, on-line surveillance of drug order entry. Int. J. Med. Inform. 2005;74:377–386
  6. Brennan TA, Leape LL, Laird NM, et al. Incidence of adverse events and negligence in hospitalized patients. Results of Harvard medical practice study I. New Engl. J. Med. 1991;324:370–376
  7. Vincent C, Neale G, Woloshynowych M. Adverse events in British hospitals: preliminary retrospective record review. BMJ. 2001;322:517–519
  8. Kilbridge P, Classen D, et al. A process model of inpatient medication management and information technology interventions to improve patient safety. VHA's research series. 2001;
  9. Franklin BD, Vincent C, Schachter M, et al. The incidence of prescribing errors in hospital inpatients: an overview of the research methods. Drug Safety. 2005;28:891–900
  10. Griffith R, Griffiths H, Jordan S. Administration of medicine. part 1: the law and nursing. Nurs. Stand. 2003;18:47–53
  11. Jordan S, Tunnicliffe C, Sykes A. Minimizing side-effects: the clinical impact of nurse-administered ‘side effect’ checklist. J Adv. Nurs. 2002;37:155–165
  12. Lesar TS, Briceland LL, Stein DS. Factors related to errors in medication prescribing. JAMA. 1997;277:312–317
  13. Dean B, Schachter M, Vincent C, et al. Causes of prescribing errors in hospital inpatients: a prospective study. Lancet. 2002;359:1373–1378
  14. Milstein A, Galvin RS, Delbanco SF, et al. Improving the safety of health care: the leapfrog initiative. Eff. Clin. Pract. 2000;3:313–316
  15. Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety. Arch. Int. Med. 2003;163:1409–1416
  16. Eslami S, Abu-Hanna A, de Keizer NF. Evaluation of outpatient computerized physician medication order entry systems; a systematic review. J. Am. Med. Inform. Assoc. 2007;14:400–406
  17. Aarts J, Berg M. Same system, different outcomes: comparing the implementation of computerized physician order entry in two Dutch hospitals. Method. Inform. Med. 2006;45:53–61
  18. Oppenheim MI, Vidal C, Velasco FT, et al. Impact of a computerized alert during physician order entry on medication dosing in patients with renal impairment. In: Proceedings of AMIA Symposium. 2002;p. 577–581
  19. Dubeshter B, Griggs J, Angel C, Loughner J. Chemotherapy dose limits set users of a computer order entry system. Hosp. Pharm. 2006;41:136–142
  20. Overhage JM, Tierney M, McDonald CJ. Computer reminders to implement preventive care guidelines for hospitalized patients. Arch. Int. Med. 1996;156:1551–1556
  21. Butler J, Speroff T, Arbogast PG, et al. Improved compliance with quality measures at hospital discharge with a computerized physician order entry system. Am. Heart J. 2006;151:643–653
  22. Teich JM, Merchia PR, Schmiz JL, et al. Effects of computerized physician order entry on prescribing practices. Arch. Int. Med. 2000;160:2741–2747
  23. Chertow GM, Lee J, Kuperman GJ, et al. Guided medication dosing for inpatients with renal insufficiency. JAMA. 2001;286:2839–2844
  24. Kawahara NE, Jordan FM. Influencing prescribing behavior by adapting computerized order-entry pathways. Am. J. Hosp. Pharm. 1989;46:1798–1801
  25. Overhage JM, Tierney WM, Zhou X, et al. A randomized trial of “corollary orders” to prevent error of omission. J. Am. Med. Inform. Assoc. 1997;4:364–375
  26. Shojania KG, Yokoe D, Platt R, et al. Reducing vancomycin use utilizing a computer guideline. J. Am. Med. Inform. Assoc. 1998;5:554–562
  27. Fischer MA, Solomon DH, Teich JM, et al. Conversion from intravenous to oral medications. Arch. Int. Med. 2003;163:2585–2589
  28. Bogugki B, Jacobs BR, Hingle J, et al. Computerized reminders reduce the use of medications during shortages. J. Am. Med. Inform. Assoc. 2004;11:278–280
  29. Hulgan T, Rosenbloom ST, Hargrove F, et al. Oral quinolones in hospitalized patients: an evaluation of a computerized decision support intervention. J. Int. Med. 2004;256:349–357
  30. Galanter WL, Polikaitis A, DiDomenico RJ. A trial of automated safety alerts for inpatient digoxin use with computerized physician order entry. J. Am. Med. Inform. Assoc. 2004;11:270–277
  31. Dexter PR, Perkins S, Overhage M, et al. A computerized reminder system to increase the use of preventive care for hospitalized patients. New Engl. J. Med. 2001;345:965–970
  32. Ali NA, Mekhjian HS, Kuehn PL, et al. Specificity of computerized physician order entry has a significant effect on the efficiency of workflow for critically ill patients. Crit. Care Med. 2005;33:110–114
  33. Peterson JF, Kuperman GJ, Shek C, et al. Guided prescription of psychotropic medications for geriatric inpatients. Arch. Int. Med. 2005;165:802–807
  34. Manzo J, Sinnett MJ, Sosnowski F, et al. Case study: challenges, successes and lessons learned from implementing computerized physician order entry (CPOE) at two distinct health systems: implication of CPOE on pharmacy and medication-use process. Hosp. Pharm. 2005;40:420–429
  35. Judge J, Field TS, DeFlorio M, et al. Prescribers’ responses to alerts during medication ordering in long term care setting. J. Am. Med. Inform. Assoc. 2006;13:385–390
  36. Chisolm DJ, McAlearney AS, Veneris S, et al. The role of computerized order sets in pediatric inpatient asthma treatment. Pediatr. Allergy Immu. 2006;17:199–206
  37. Ozdas A, Speroff T, Waitman R, et al. Integrating “best of care” protocols into clinicians’ workflow via care provider order entry: impact on quality-of-care indications for acute myocardial infarction. J. Am. Med. Inform. Assoc. 2006;13:188–196
  38. Asaro PV, Sheldahl AL, Char DM. Embedded guideline information without patient specificity in a commercial emergency department computerized order-entry system. Acad. Emerg. Med. 2006;13:452–458
  39. McAlearney AS, Chisolm D, Veneris S, et al. Utilization of evidence-based computerized order sets in pediatrics. Int. J. Med. Inform. 2006;75:501–512
  40. Dexter PR, Perkins SM, Maharry KS, et al. Inpatient computer-based standing orders versusphysician reminders to increase influenza and pneumococcal vaccination rates. JAMA. 2004;292:2366–2371
  41. Del Fiol G, Rocha BH, Nohama P. Design, implementation and evaluation of a clinical decision support system to prevent adverse drug events. Stud. Health Technol. Inform. 2000;77:740–744
  42. Nightingale PG, Adu D, Richards NT, et al. Implementation of rules based computerized bedside prescribing and administration: intervention study. BMJ. 2000;320:750–753
  43. Hsieh TC, Kuperman GJ, Jaggi T, et al. Characteristics and consequences of drug allergy alert overrides in a computerized physician order entry. J. Am. Med. Inform. Assoc. 2004;11:482–491
  44. Mitchell D, Usher J, Gray S, et al. Evaluation and audit of a pilot of electronic prescribing and drug administration. J. Inform. Technol. Healthc. 2004;2:19–29
  45. Weiner M, Gress T, Thiemann DR, et al. Contrasting views of physician and nurses about an inpatient computer-based provider order-entry system. J. Am. Med. Inform. Assoc. 1999;6:234–244
  46. Thompson DA, Duling L, Holzmueller GC, et al. Computerized physician order entry, a factor in medication errors: descriptive analysis of events in the intensive care unit safety reporting system. J. Clin. Out. Manag. 2005;12:407–412
  47. Horsky J, Kuperman GJ, Patel VL. Comprehensive analysis of a medication dosing error related to CPOE. J. Am. Med. Inform. Assoc. 2005;12:377–382
  48. Mirco A, Campos L, Falcao F, et al. Medication error in an internal medicine department. Evaluation of a computerized prescription system. Pharm World Sci. 2005;27:351–352
  49. Eslami S, Abu-Hanna A, de Keizer NF, de Jonge E. Error associated with applying decision support by suggesting default doses for aminoglycosides. Drug Safety. 2006;29:803–809
  50. Bates DW, Leape LL, Cullen DJ, et al. Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA. 1998;280:1311–1316
  51. Evans RS, Pestotnik SL, Classen DC, et al. A computer-assisted management program for antibiotics and other antiinfective agents. New Engl. J. Med. 1998;338:232–238
  52. Bates DW, Teich JM, Lee J, et al. The impact of computrized physician order entry on medication error prevention. J. Am. Med. Inform. Assoc. 1999;6:313–321
  53. Evans RS, Pestotnik SL, Classen DC, et al. Evaluation of computer-assisted antibiotic-dose monitor. Ann. Pharmaco. 1999;1026–1031
  54. Mullett CJ, Evans RS, Christenson JC, et al. Development and impact of a computerized pediatric antiinfective decision support program. Pediatrics. 2001;108:E75
  55. Igboechi CA, Ng CL, Yang CS, et al. Impact of computerized prescriber order entry on medication errors at an acute tertiary care hospital. Hosp Pharm. 2003;38:pp. 277–231
  56. Cordero L, Kuehn L, Kumar RR, et al. Impact of computerized physician order entry on clinical practice in a newborn intensive care unit. J. Perinatol. 2004;24:88–93
  57. Krampera M, Venturini F, Benedetti F, et al. Computer-based drug management in a bone marrow transplant unit: a suitable tool for multiple prescriptions even in critical condition. Br. J. Hematol. 2004;125:50–57
  58. Potts AL, Barr FE, Gregory DF, et al. Computerized physician order entry and medication errors in a pediatric critical care unit. Pediatrics. 2004;113:59–63
  59. Taylor R, Manzo J, Sinnett M. Quantifying value for physician order entry systems: a balance of cost and quality. Healthc. Financ. Manage. 2002;56:44–48
  60. Bizovi KE, Beckley BE, McDade MC, et al. The effect of computer-assisted prescription writing on emergency department prescribing errors. Acad. Emerg. Med. 2002;9:1168–1175
  61. Mekhjian HS, Kumar RR, Kuehn L, et al. Immediate benefits realized following implementation of physician order entry at an academic medical center. J. Am. Med. Inform. Assoc. 2002;9:529–539
  62. King WJ, Paice N, Rangrej J, et al. The effect of computized physician order entry on medication errors and adverse drug events in pediatric inpatients. Pediatrics. 2003;112:506–509
  63. Galanter WL, Didomenico RJ, Polikaitis A. A trial of automated decision support alerts for contraindicated medications using computerized physician order entry. J. Am. Med. Inform. Assoc. 2005;12:269–274
  64. Shulman R, Singer M, Goldstone J, Bellingan G. Medication errors: a prospective cohort study of hand-written and computerized physician order entry in the intensive care unit. Crit. Care. 2005;9:p. R516–21
  65. Upperman JS, Staley P, Friend K, et al. The impact of hospital-wide computerized physician order entry on medical errors in a pediatric hospital. J. Pediatr. Surg. 2005;40:50–59
  66. Kim GR, Chen AR, Arceci RJ, et al. Error reduction in pediatric chemotherapy. Arch. Pediatr. Adolesc. Med. 2006;160:495–498
  67. Koppel R, Metlay JP, Cohen A, et al. Role of computerized physician order entry systems in facilitating medication errors. JAMA. 2005;293:1197–1203
  68. Nebeker JR, Hoffman JM, Weir CR, et al. High rates of adverse drug events in a highly computerized hospital. Arch. Int. Med. 2005;165:1111–1116
  69. Han YY, Carcillo JA, Venkataraman ST, et al. Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system. Pediatrics. 2006;116:1506–1512
  70. Del Beccaro MA, Jeffries HE, Eisenberg MA, Harry ED. Computerized provider order entry implementation: no association with increased mortality rates in an intensive care unit. Pediatrics. 2006;118:290–295
  71. Tierney WM, Miller ME, Overhage JM, et al. Physician inpatient order writing on microcomputer workstations: effects on resource utilization. J. Am. Med. Inform. Assoc. 1993;269:379–383
  72. Cheng CH, Goldstein MK, Geller E, et al. The effects of CPOE on ICU workflow: an observational study. In: Proceeding of AMIA. 2003;p. 150–154
  73. Rosenbloom ST, Geissbuhler AJ, Dupont WD, et al. Effect of CPOE user interface design on user-initiated access to educational and patient information during clinical care. J. Am. Med. Inform. Assoc. 2005;12:458–473
  74. Kaushal R, Jha AK, Franz C, et al. Return on investment for a computerized physician order entry system. J. Am. Med. Inform. Assoc. 2006;13:261–266
  75. Beuscart-Zephir MC, Pelayo S, Anceaux F, et al. Impact of CPOE on doctor–nurse cooperation for the medication ordering and administration process. Int. J. Med. Inform. 2005;74:629–641
  76. Abookire SA, Teich JM, Sandige H, et al. Improving allergy alerting in a computerized physician order entry system. In: Proceedings of the AMIA. 2000;p. 2–6
  77. Bates DW, Boyle DL, Teich JM. Impact of computerized physician order entry on physician time. In: Proceedings of the Annual Symposium Computer Application in Medical Care. 1994;p. 996
  78. Shu K, Boyle D, Spurr C, et al. Comparison of time spent writing orders on paper with computerized physician order entry. In: Proceedings of the Medical Informatics. 2001;p. 1207–1211
  79. Banet GA, Jeffe DB, Williams JA, Asaro PV. Effects of implementing computerized practitioner order entry and nursing documentation on nursing workflow in an emergency department. J. Healthc. Inform. Manage. 2006;20:45–54
  80. Costa AL, de Oliveira MMB, Rde O Machado. An information system for drug prescription and distribution in public hospital. Int. J. Med. Inform. 2004;73:371–381
  81. Rosenbloom ST, Talbert D, Aronsky D. Clinicians’ perceptions of clinical decision support integrated into computerized provider order entry. Int. J. Med. Inform. 2004;73:433–441
  82. Murff H, Kannry J. Physician satisfaction with two order entry system. J. Am. Med. Inform. Assoc. 2001;8:499–509
  83. Lee F, Teich JM, Spurr CD, Bates DW. Implementation of physician order entry: user satisfaction and self-reported usage patterns. J. Am. Med. Inform. Assoc. 1996;3:42–55
  84. Bomba D, Land T. The feasibility of implementing an electronic prescribing decision support system: a case study of an Australian public hospital. Aust. Health Rev. 2006;30:380–388
  85. Oren E, Shaffer ER, Guglielmo BJ. Impact of emerging technologies on medication errors and adverse drug events. Am. J. Health-Syst. Pharm. 2003;60:1447–1458
  86. Kuperman GI, Gibson RF. Computer physician order entry: benefits, costs, and issues. Ann. Int. Med. 2003;139:31–39
  87. Chaudhry B, Wang J, Wu S, et al. Systematic review: impact of health information technology on quality, efficiency, and cost of medical care. Ann. Int. Med. 2006;144:E12–E22
  88. Van der Sijs H, Aarts J, Vulto A, et al. Overriding of drug safety alerts in computerized physician order entry. J. Am. Med. Inform. Assoc. 2006;13:138–147
  89. Grag AX, Adhikari NKJ, McDonald H, et al. Effect of computerized clinical decision support systems on practitioner performance and patient outcomes. JAMA. 2005;293:1223–1238
  90. Niinimaki J, Forsstrom J. Approaches for certification of electronic prescription software. Int. J. Med. Inform. 1997;47:175–182
  91. Kaplan B. Evaluating informatics applications—some alternative approaches: theory, social interactionism, and call for methodological pluralism. Int. J. Med. Inform. 2001;64:39–56
  92. Ammenwerth A, Talmon J, Ash JS, et al. Impact of CPOE on mortality rates—contradictory findings, important messages. Method. Inform. Med. 2006;45:586–594

PII: S1386-5056(07)00169-4

doi: 10.1016/j.ijmedinf.2007.10.001

International Journal of Medical Informatics
Volume 77, Issue 6 , Pages 365-376 , June 2008

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